Started in 1469 in late Gothic style, probably based on a design of Marino di Marco Cedrino, the Basilica was completed in 1587 with its facade in late renaissance style.

In 1468 the Bishop of Recanati Niccolò delle Aste decided on the construction of the current temple, started the following year.

After the bishop's death in 1469, the work was taken to heart by Pope Paul IIth who in 1464 while still a cardinal had been miraculously cured in the Holy House.